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early data shows strong links between childhood stress and the accelerated shortening of telomeres.
Researchers have also found that telomeres shorten at a higher rate when exposed to toxins, such as radiation or cigarette smoke.
those who lived the longest had inherited a hyperactive version of an enzyme called telomerase that rebuilds telomeres.
really interesting article…I think the gene in question here has many effects throughout the body, including being related to oxidative stress.
Resveratrol doesn’t help so much with total lifespan; it just activates the stress response; which is helpful for warding off disease and various pre-mature deaths.
One of the most notable advances occurred in 2008, when Cuervo’s research team blocked the aging process in mouse livers by stopping the accumulation of harmful proteins within cells of the liver. You read that right, she stopped aging. Cuervo achieved that miracle by adding a lysosomal membrane receptor, LAMP-2A, to older mice. Basically, LAMP-2A removes cellular waste, which preserves the integrity of the cell, which in turn improves the function of the organ. “The more cells age, the less efficient they become at clearing out toxins,” Cuervo said. According to Cuervo, LAMP-2A not only takes out the trash, it appears to rejuvenate the cell.
I consider that if funding is sufficient we have a 50/50 chance of developing technology within about 25 to 30 years from now that will, under reasonable assumptions about the rate of subsequent improvements in that technology, allow us to stop people from dying of aging at any age—equivalent to the effect of today’s antiretrovirals against HIV. There are a few big caveats to that statement, though. The first is that it’s only a 50 percent chance. Any technological prediction as far in the future as 25 to 30 years is necessarily very speculative, and if you asked me how soon I thought we would have a 90 percent chance of defeating aging, I wouldn’t even be willing to bet on 100 years. But I think a 50 percent chance is well worth shooting for—don’t you? The second caveat is that aging won’t be totally defeated by the initial versions of this technology. We’ll have to carry on improving it at a reasonable rate in order to keep aging permanently at bay.
Female athlete sets new shot put record at age 100 - Yahoo! News
“The oldest female athlete at the World Masters Games in Sydney has broken a world record in the shot put — at the age of 100. All eyes were on Ruth Frith, from Brisbane, as she arrived for day two of the World Masters Games, hoping to win gold in the shot put and feeling pretty confident as she was the only competitor in the over-100s category. But her 4.07 metre (13 ft 4.2 in) throw on Sunday didn’t just win her gold, but also broke a world record. “As long as I didn’t foul I was going to win it,” Frith told Reuters Television. The great-grandmother is also a keen hammer and javelin thrower and believes other pensioners should follow her example. Frith trains five days a week, regularly lifting 35 kg (77 lb) weights. She doesn’t drink or smoke and she doesn’t eat vegetables either, claiming she hasn’t liked them since she was young.”
Metformin has been shown to increase the lifespan of mice by approximately 20%. Some have theorized that it may also extend human lifespan, and some have suggested that human trials be conducted. (http://www.drugs.com/news/scientists-discover-anti-ageing-metformin-diabetes-drug-3276.html , http://www.dailymail.co.uk/health/article-1217481/Cheap-diabetes-pill-help-defy-ageing-process.html)
pretty cool :)
By deleting a single gene from a mouse’s genetic makeup, they’ve enabled it to suffer fewer age related ailments and live 20% longer. On humans, that’d be about 16 bonus years. So what exactly did those crazy scientists do? They bred mice with the “gene that produces the protein S6 kinase 1 (S6K1)” disabled. The effects of this are a bit extreme: The change mimicked the effect of keeping the mice on a calorie-restricted diet. Severely restricting the diets of yeast, bacteria, mice and primates have granted these animals unnaturally long lives.
The diseases causes wrinkly skin and is known as wrinkly skin disorder.
Pretty cool stuff….
HI-ORAC-8 from UV Exposures Proven to Reduce Photoaging and Risk of Melanoma
This is just basic stuff that I think everyone but me knows. I don’t really care that much about photoaging or skin appearance, but these concepts are interesting, and I ever got to the point where I was wrinkled beyond my comfort zone, I’d be in to this.
Cool little infographic showing how we’re making steady progress vs. aging.
Life Expectency in the USA has increased and total deaths have fallen
